Results
| PMID | 21733505 |
| Gene Name | C3 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 384 |
| Population details | 384 (147 controls without endometriosis or infertility, 214 subjects with endometriosis, with or without infertility, 72 subjects with endometriosis without known infertility problems, 73 subjects with endometriosis-associated infertility) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | LOXL4, C3 |
| Other associated phenotypes |
Endometriosis-associated infertility |
|
Fertil Steril. 2011 Aug;96(2):512-5. doi: 10.1016/j.fertnstert.2011.06.001. Epub Ruiz, Lynnette A| Dutil, Julie| Ruiz, Abigail| Fourquet, Jessica| Abac, Sonia| Laboy, Joaquin| Flores, Idhaliz Department of Microbiology, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico 00716-2348, USA. This study was conducted to assess genetic associations with endometriosis in a Puerto Rican population. Statistically significant differences in the allelic frequencies and genotype distribution of genetic variants in lysyl oxidase-like protein 4 (LOXL4) and complement component 3 (C3) were documented in patients with endometriosis-associated infertility versus controls, and in patients with endometriosis versus controls, respectively. In women who have the risk genotype at both single-nucleotide polymorphisms, the estimated risk for endometriosis nearly doubled. Mesh Terms: Adult| Amino Acid Oxidoreductases/*genetics| Case-Control Studies| Chi-Square Distribution| Complement C3/*genetics| Endometriosis/complications/enzymology/*genetics/immunology| Female| Gene Frequency| Genetic Predisposition to Disease| Humans| |
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